A case of PBC-AIH overlap syndrome with systemic sclerosis and liver scar

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  • Yamashita Nobuyuki
    The Center for Liver Disease, Shin-Kokura Hospital
  • Miyagi Yugo
    Department of Internal Medicine, Shin-Kokura Hospital
  • Simoda Shinji
    Medicine and Biosystemic Science, Kyushu University, Graduate School of Medical Science
  • Hori Fumiko
    The Center for Liver Disease, Shin-Kokura Hospital
  • Tanimoto Hironori
    The Center for Liver Disease, Shin-Kokura Hospital
  • Ichiki Yasunori
    Department of Internal Medicine, Japan Community Health Care Organization Kyushu Hospital
  • Yamamoto Hidetaka
    Department of Anatomic Pathology, Pathological Science, Graduate School of Medical Sciences, Kyushu University
  • Nomura Hideyuki
    The Center for Liver Disease, Shin-Kokura Hospital

Bibliographic Information

Other Title
  • 全身性強皮症に自己免疫性肝炎と原発性胆汁性胆管炎のオーバーラップ症候群を合併し，瘢痕肝の所見を呈した一例
  • 症例報告 全身性強皮症に自己免疫性肝炎と原発性胆汁性胆管炎のオーバーラップ症候群を合併し,瘢痕肝の所見を呈した一例
  • ショウレイ ホウコク ゼンシンセイ キョウ ヒショウ ニ ジコ メンエキセイ カンエン ト ゲンパツセイ タンジュウセイタンカンエン ノ オーバーラップ ショウコウグン オ ガッペイ シ,ハンコン カン ノ ショケン オ テイシタ イチレイ

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Description

<p>A sixties year-old man with a history of systemic sclerosis was referred to our hospital because of elevated liver enzymes. Abdominal finding of images showed massive hepatic necrosis near the diaphragm. Elevated ALP, AMA positive, and histological findings as PBC and elevated ALT and histological interface hepatitis findings as AIH indicated the diagnosis as overlap syndrome. Even though this case had good response with corticosteroid and UDCA therapy, hepatic scar and deformation remained after 6 months later. Liver biopsy must be considered aggressively in case of patients with collagen diseases who had elevated liver enzymes.</p>

Journal

  • Kanzo

    Kanzo 57 (9), 487-495, 2016

    The Japan Society of Hepatology

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