D-Galactosamine肝炎における肝の血液循環障害と病理組織学的変化との関係について

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タイトル別名
  • Relationship between the circulatory disturbance and the histological changes in the experimental D-galactosamine induced hepatitis in rats
  • D Galactosamine カンエン ニ オケル カン ノ ケツエキ ジュ

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説明

Hepatic blood flow, oxygen consumption and bile production in the isolated perfused rat liver of D-galactosamine induced hepatitis were measured. Relationship between these parameters and the histological lesions of the liver was examined.<BR>A marked decrease in hepatic blood flow, a decrease in oxygen consumption and a decrease in bile production were recorded. A decrease in hepatic blood flow was thought to have an intimate relationship with following histological changes of the liver; 1) a decrease in sinusoidal space resulted from liver cell swelling and Kupffer cell proliferation, 2) leucocytic infiltration in many sinusoids and 3) destruction of sinusoids.<BR>The localized circulatory disturbance in the liver lobule which was induced by the morphological lesions described above is thought to play an important role in development of the focal or widespread necrosis of the liver lobule of the D-galactosamine hepatitis.

収録刊行物

  • 肝臓

    肝臓 16 (9), 579-586, 1975

    一般社団法人　日本肝臓学会

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