A case of autoimmune hepatitis with polymyositis

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  • Hayashi Manabu
    Department of Gastroenterology and Rheumatology, Fukushima Medical University School of Medicine
  • Abe Kazumichi
    Department of Gastroenterology and Rheumatology, Fukushima Medical University School of Medicine
  • Saito Rie
    Department of Gastroenterology and Rheumatology, Fukushima Medical University School of Medicine
  • Sato Shuzo
    Department of Gastroenterology and Rheumatology, Fukushima Medical University School of Medicine
  • Monoe Kyoko
    Department of Gastroenterology and Rheumatology, Fukushima Medical University School of Medicine
  • Kanno Yukiko
    Department of Gastroenterology and Rheumatology, Fukushima Medical University School of Medicine
  • Saito Hironobu
    Department of Gastroenterology and Rheumatology, Fukushima Medical University School of Medicine
  • Iwadate Haruyo
    Department of Gastroenterology and Rheumatology, Fukushima Medical University School of Medicine
  • Takahashi Atsushi
    Department of Gastroenterology and Rheumatology, Fukushima Medical University School of Medicine
  • Ohira Hiromasa
    Department of Gastroenterology and Rheumatology, Fukushima Medical University School of Medicine

Bibliographic Information

Other Title
  • 多発性筋炎を合併した自己免疫性肝炎の１例
  • 症例報告 多発性筋炎を合併した自己免疫性肝炎の1例
  • ショウレイ ホウコク タハツセイ キンエン オ ガッペイ シタ ジコ メンエキセイ カンエン ノ 1レイ

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Abstract

We report the case of a 72-year-old woman diagnosed with autoimmune hepatitis (AIH) complicated by polymyositis (PM). She was admitted to the hospital owing to elevated serum aminotransferase. Serum IgG was 3617 mg/dl and anti-nuclear antibody was positive (×320). Liver needle biopsy findings were consistent with AIH and this was corroborated by her score of 18 on the International Autoimmune Hepatitis Group (IAIHG) scoring system, which is consistent with definite AIH. Serum creatinine kinase was also elevated and she complained of lower-extremity muscle weakness. Muscle biopsy histology was consistent with PM. Based on these findings, she was diagnosed with AIH complicated by PM. Serum aminotransferase improved after treatment with prednisolone. AIH complicated by PM should be considered when a patient complains of muscle weakness or exhibits elevated serum creatinine kinase.<br>

Journal

  • Kanzo

    Kanzo 52 (6), 344-350, 2011

    The Japan Society of Hepatology

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