The effects of repeated administration of phenobarbital (Ph) and Bucolome (BC) on the biliary excretion ofindocyanine green (ICG) in rats.

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  • KITANI Kenichi
    First Laboratory of Clinical Physiology, Tokyo Metropolitan Institute of Gerontology
  • MORITA Yoshiko
    First Laboratory of Clinical Physiology, Tokyo Metropolitan Institute of Gerontology
  • MIURA Reiko
    First Laboratory of Clinical Physiology, Tokyo Metropolitan Institute of Gerontology
  • KANAI Setsuko
    First Laboratory of Clinical Physiology, Tokyo Metropolitan Institute of Gerontology

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Other Title
  • PhenobarbitalおよびBucolomeの連続投与がラットのindocyanine green最大排泄値におよぼす影響
  • Phenobarbital オヨビ Bucolome ノ レンゾク トウヨ ガ

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Abstract

The effect of repeated administration of Ph (8mg/100g/day, ip, for 4 days) and BC (50mg/100g/day, oral, 4 days) on the biliary excretion of ICG were examined in Wistar male rats under the continuous ICG infusion. Both treatments significantly decreased the rate of increase in plasma ICG concentration, and increased the bile flow rate compared with control rats. However, ICG concentration in bile was significantly decreased in both treated rat groups. ICG excretion rate was not increased in treated groups, rather showed the tendency to decrease, though insignificant at the p level of 0.05. The bile flow increase by treatment of these drugs does not appear to imcrease the excretion rate of ICG.

Journal

  • Kanzo

    Kanzo 17 (7), 503-509, 1976

    The Japan Society of Hepatology

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