A case of chronic hepatitis C in which a 72-week course of pegylated interferon and ribavirin combination therapy resulted in relapse but a subsequent interferon monotherapy could induce sustained virological response

DOI Web Site Web Site 41 References
  • Okuse Chiaki
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, St. Marianna University School of Medicine
  • Kumon Daisuke
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, St. Marianna University School of Medicine
  • Kobayashi Minoru
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, St. Marianna University School of Medicine
  • Endo Akira
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, St. Marianna University School of Medicine
  • Kinoshita Yuichi
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, St. Marianna University School of Medicine
  • Noguchi Yohei
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, St. Marianna University School of Medicine
  • Izawa Naoki
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, St. Marianna University School of Medicine
  • Ozawa Shunichiro
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, St. Marianna University School of Medicine
  • Nakahara Kazunari
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, St. Marianna University School of Medicine
  • Yamada Norie
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, St. Marianna University School of Medicine
  • Okamoto Masaru
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, St. Marianna University School of Medicine
  • Takahashi Hideaki
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, St. Marianna University School of Medicine
  • Katakura Yoshiki
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, St. Marianna University School of Medicine
  • Matsunaga Kotaro
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, St. Marianna University School of Medicine
  • Matsumoto Nobuyuki
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, St. Marianna University School of Medicine
  • Ishii Toshiya
    Department of Gastroenterology, St. Marianna University School of Medicine, Yokohama Seibu Hospital
  • Yotsuyanagi Hiroshi
    Division of Infectious Diseases, Department of Internal Medicine, University of Tokyo
  • Iino Shiro
    Research Center for Liver Disease, Kiyokawa Medical Center
  • Suzuki Michihiro
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, St. Marianna University School of Medicine
  • Itoh Fumio
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, St. Marianna University School of Medicine

Bibliographic Information

Other Title
  • ペグインターフェロン・リバビリン７２週併用療法後の再燃に対し，インターフェロン単独療法の追加にて著効を得たＣ型慢性肝炎の１例
  • 症例報告 ペグインターフェロン・リバビリン72週併用療法後の再燃に対し,インターフェロン単独療法の追加にて著効を得たC型慢性肝炎の1例
  • ショウレイ ホウコク ペグインターフェロン リバビリン 72シュウ ヘイヨウ リョウホウゴ ノ サイネン ニ タイシ インターフェロン タンドク リョウホウ ノ ツイカ ニテ チョコウ オ エタ Cガタ マンセイ カンエン ノ 1レイ

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Abstract

A 59-year-old woman received pegylated interferon-α2b and ribavirin combination therapy for chronic hepatitis C. Her serum HCV RNA level was 980 KIU/ml and genotype of HCV was 1b. Although her HCV RNA became undetectable 28 weeks after the start of the therapy, duration of the therapy was extended for 72 weeks because of the late viral response. Her HCV RNA reappeared 4 weeks after the end of the therapy. Although the level of HCV RNA increased to 2600 KIU/ml 8 weeks later, it became less than 5 KIU/ml 16 weeks later. Therefore, she was re-treated 3 times a week with 9 MU of consensus interferon. Since she remained negative for HCV RNA thereafter, the therapy was ended 24 weeks after its commencement. Finally, she obtained a sustained virological response.<br>

Journal

  • Kanzo

    Kanzo 49 (11), 495-500, 2008

    The Japan Society of Hepatology

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