Antibody-dependent cell-mediated cytotoxicity (ADCC) in liver diseases

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  • NAKANO Mamoru
    The Third Division, Department of Internal Medicine, Faculty of Medicine, Niigata University

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Other Title
  • 肝疾患におけるantibody-dependent cell-mediated cytotoxicity (ADCC)に関する研究
  • カン シッカン ニ オケル antibody dependent cell m
  • II. Relationship between ADCC activity of peripheral blood lymphocytes and mononuclear cell infiltration in the liver
  • 第2報 末梢血リンパ球のADCC活性と肝組織内単核細胞浸潤の関連性

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Description

In order to clarify the participation of ADCC in the mechanism of liver cell injury, ADCC activity of peripheral blood lymphocytes from patients with acute viral hepatitis and chronic liver diseases was investigated and compared with mononuclear cell infiltration in liver tissues obtained by needle biopsy.<BR>ADCC activity was decreased significantly in initial stage of acute viral hepatitis, chronic hepatitis (active), chronic hepatitis (inactive), persistent hepatitis and primary biliary cirrhosis. This activity was normalized at the recovery stage of acute viral hepatitis.<BR>ADCC activity was compared with degree of momnuclear cell infiltration in portal tracts and hepatic lobules. The grade of mononuclear cell infiltration in hepatic lobules was in inverse proportion to ADCC activity. Therefore, it is suggested that K cell was mobilized into the liver and ADCC was participated in liver cell injury.<BR>In normal subjects, ADCC activity was suppressed almost completely with heataggregated IgG as a model of immune complex. On the other hand, because the suppression was incomplete in patients with chronic hepatitis (active), chronic hepatitis (inactive) and persistent hepatitis, it could not be denied that Fc-receptor of K cell was blocked by immune complex.

Journal

  • Kanzo

    Kanzo 21 (11), 1452-1458, 1980

    The Japan Society of Hepatology

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