Morphological studies on the intrahepatic bile duct of primary biliary cirrhosis

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  • NAKANUMA Yasuni
    2nd Department of Pathology, School of Medicine, Kanazawa University
  • OHTA Goroku
    2nd Department of Pathology, School of Medicine, Kanazawa University

Bibliographic Information

Other Title
  • 原発性胆汁性肝硬変の肝内胆管系に関する形態学的研究
  • ゲンパツセイ タンジュウセイ カンコウヘン ノ カンナイ タンカンケイ ニ カ
  • II. Morphological studies on the intrahepatic bile duct of early PBC by serial sections
  • II 連続切片法による早期PBCの肝内胆管崩壊の観察

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Abstract

Primary biliary cirrhosis is well known to be morphologically characterized by progressive destruction of the interlobular bile ducts of the liver. In order to know any morphological changes of the ducts which are found prior to their destruction in the livers, serial sections of wedge liver biopsies of 2 cases of early PBC were carefully examined.<BR>Three types of morphological changes were found just before complete disappearance of the bile ducts on the serial sections: 1. periductal cellular reaction (small round cells or epithelioid granuloma), 2. periductal edema, 3. periductal mild fibrosis or non-significant changes. These morphological changes were occasionally associated with cystic dilatation or narrowing of the lumina of the bile ducts.

Journal

  • Kanzo

    Kanzo 17 (11), 809-819, 1976

    The Japan Society of Hepatology

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