An autopsy case of primary squamous cell carcinoma of the liver

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  • Dohmen Kazufumi
    Internal Medicine, Chihaya Hospital
  • Tanaka Hirofumi
    Internal Medicine, Chihaya Hospital
  • Haruno Masatora
    Radiology, Chihaya Hospital
  • Fujiwara Hiroaki
    Laboratory of Oral Pathology, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University
  • Kobayashi Ieyoshi
    Laboratory of Oral Pathology, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University
  • Kiyoshima Tamotsu
    Laboratory of Oral Pathology, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University
  • Shimoda Shinji
    Medicine and Biosystemic Science, Graduate School of Medical Science, Kyushu University
  • Sakai Hidetaka
    Laboratory of Oral Pathology, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University

Bibliographic Information

Other Title
  • 原発性肝扁平上皮癌の1剖検例
  • 症例報告 原発性肝扁平上皮癌の1剖検例
  • ショウレイ ホウコク ゲンパツセイ ギモ ヘンペイ ジョウヒガン ノ 1 ボウケンレイ

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Abstract

An 88-year-old Japanese female was referred to our hospital because of multiple tumors in the liver. On admission, her temparature was 37.2°C. Her data on admission were: white blood cell counts 14,960/μl, C-reactive protein 10.57 mg/dl, total bilirubin 0.42 mg, ALT 24 IU/l, ALP 384 IU/l, γ GTP 109 IU/l, serum albumin 3.2 g/dl. Hepatitis B antigen and hepatitis C antibody in serum were both negative. Alpha-fetoprotein and carcinoembryonic antigen were within normal range, however, CA19-9 was slightly elevated to 73.6 U/ml. Enhanced computed tomography revealed multiple low attenuation masses with enhanced peripheral rims. She was suspected as having gallbladder cancer and metastatic liver cancer. She took a palliative therapy and died of hepatic failure 73 days after the admission. An autopsy was performed. The cut surface of the expansive tumor occupying the right lobe of the liver contained necrotic lesions. Histologically, the tumor revealed a well to poorly-differentiated squamous cell carcinoma showing keratinized cells. Existing liver had no evidence of chronic hepatitis, cysts or intrahepatic stones. To our knowledge, only seven cases of primary squamous cell carcinoma of the liver have been reported in Japan.<br>

Journal

  • Kanzo

    Kanzo 53 (3), 183-190, 2012

    The Japan Society of Hepatology

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