インスリン動態よりみた肝障害時の糖代謝異常に関する研究

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タイトル別名
  • Studies on the Abnormalities of Carbohydrate Metabolism and Insulin Secretion in Liver Injuries
  • インスリン ドウタイ ヨリ ミタ カン ショウガイジ ノ トウ タイシャ イジ

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抄録

In order to investigate the abnormalities of carbolydrate metabolism and insulin secretion in liver diseases, we studied 100g oral glucose tolerance test (GTT) with simultaneous determination of serum immunoreactive insulin (IRI) in 323 subjects. The 30' ΔIRI/ΔBS was calculated on the basis of increments in 30 minutes's blood glucose and IRI after oral glucose load. <BR>The 30' ΔIRI/ΔBS was generally higher in liver diseases than in diabetes mellitus. In acute stage of acute hepatitis, the level of 30' ΔIRI/ΔBS was lower than in normal subjects while it became within normal range in the recovery stage. In the liver diseases with diabetes mellitus, the mean value of 30' ΔIRI/ΔBS was almost intermediate level between that of diabetes mellitus and liver diseases. Liver cirrhosis which showed the lowest level of 30' ΔIRI/ΔBS among liver diseases seemed to be almost similar state of carbohydrate metabolism as in diabetes mellitus. <BR>There was negative correlation between the level of 30' ΔIRI/ΔBS and the degree of abnormalities of GTT. The value of 30' ΔIRI/ΔBS was higher in liver diseases with diabetic type of GTT than in liver diseases with diabetes mellitus. In addition, the low level of 30' ΔIRI/ΔBS observed in the cases of chronic inactive hepatitis with diabetic pattern of GTT seemed to be due to rather pancreatic β-cell injuries than hepatocellular damages. <BR>From the analysis of ∑IRI and ∑IRI/∑BS levels, hypersecretion of insulin would play the important role for their high levels in the liver injuries.

収録刊行物

  • 肝臓

    肝臓 18 (9), 615-624, 1977

    一般社団法人　日本肝臓学会

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