Clinical characteristics of patients with acute hepatitis B genotype A

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  • Ishii Koji
    Department of Gastroenterology and Hepatology, Toho University School of Medicine
  • Kogame Michio
    Department of Gastroenterology and Hepatology, Toho University School of Medicine
  • Shiratori Misato
    Department of Gastroenterology and Hepatology, Toho University School of Medicine
  • Shinohara Mie
    Department of Gastroenterology and Hepatology, Toho University School of Medicine
  • Wakui Noritaka
    Department of Gastroenterology and Hepatology, Toho University School of Medicine
  • Higami Katsuya
    Research Center for Hepatitis and Immunology, International Medical Center of Japan, Konodai Hospital
  • Sumino Yasukiyo
    Department of Gastroenterology and Hepatology, Toho University School of Medicine

Bibliographic Information

Other Title
  • Ｇｅｎｏｔｙｐｅ　Ａの急性Ｂ型肝炎の臨床的特徴
  • Genotype A ノ キュウセイ Bガタ カンエン ノ リンショウテキ トクチョウ

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Abstract

Recently, an association between hepatitis B virus (HBV) genotype and clinical characteristics has been identified. Of special interest is the recent increase of acute hepatitis B (AHB) genotype A observed in urban areas of Japan. To determine the clinical characteristics associated with AHB genotype A, we compared admission serum levels of alanine aminotransferase, total bilirubin, and HBV markers for patients infected with AHB genotype A (A group) and AHB genotypes B or C (non-A group). Serum level of total bilirubin was significantly higher in the A group than in the non-A group. Serum titers of HBV-DNA and HBe antigen were also significantly higher in the A group, and these may be related to the production of certain types of HBe antigen in genotype A HBV while the other genotypes produce only a single variant of the antigen. Although patients in the non-A group did not develop to chronic hepatitis, 3 of 11 patients in the A group progressed to chronic hepatitis, suggesting that serum HBe antigen promotes immunologic tolerance to persistent viral infection.<br>

Journal

  • Kanzo

    Kanzo 51 (7), 397-399, 2010

    The Japan Society of Hepatology

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