Elevated serum ALT levels following hyperferritinemia in CHC patients receiving pegylated interferon (PEG-IFN) therapy and availability of phlebotomy

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  • Ｃ型慢性肝炎に対するＰＥＧ－ＩＦＮ療法施行中にみられるＡＬＴおよびフェリチンの上昇と瀉血療法の有用性
  • 症例報告 C型慢性肝炎に対するPEG-IFN療法施行中にみられるALTおよびフェリチンの上昇と瀉血療法の有用性
  • ショウレイ ホウコク Cガタ マンセイ カンエン ニ タイスル PEG IFN リョウホウ シコウ チュウ ニ ミラレル ALT オヨビ フェリチン ノ ジョウショウ ト シャケツ リョウホウ ノ ユウヨウセイ

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Abstract

Elevated serum ALT levels sometimes have been observed in CHC patients receiving pegylated interferon (PEG-IFN) therapy. However the reason for this elevation hasn't been clarified and in these cases we often hasitate to continue PEG-IFN therapy. We experienced three ALT-elavated cases following hyperferritinemia. And in one of them phlebotomy was performed. PEG-IFN therapy is very useful for viral elimination, remission of hepatitis, and suppression of HCC. However when serum ALT levels elevate following hyperferritinemia, it is speculated that activity of hepatitis and liver fibrosis become worse. In such cases phlebotomy may be effective.<br>

Journal

  • Kanzo

    Kanzo 51 (7), 371-378, 2010

    The Japan Society of Hepatology

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