3'. Methyl-4-dimethylaminoazobenzene短期間投与後に発生したラット肝のcholangiofibrosis

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タイトル別名
  • Cholangiofibrosis induced by short-term feeding of 3'-methyl-4-dimethylaminoazabenzene (3'-Me-DAB).
  • 3 -Methyl-4-dimethylaminoazobenzene タンキカン トウヨ ゴ ニ ハッセイ シタ ラット ギモ ノ cholangiofibrosis

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説明

A specific lesion of the liver was observed in the rat fed on a basic diet for up to 82 weeks after a short term (1, 2, 4 weeks) administration of 3'-Me-DAB.<BR>Proliferation of oval cells was seen in the periportal area shortly after the cessation of 3'-Me-DAB administration for 4 weeks. This proliferation at the same time, showed ducts formed by atypical epithelial cells.<BR>Cholangiofibrosis, a proliferation of ducts with fibrous tissue, developed into nodules and continued to grow, while the oval cells gradually disappeared after the cessation of 3'-Me-DAB. There was found to be a close relationship in distribution among the proliferation of the oval cells, the appearance of atypical ducts, and the formation of nodules of cholangiofibrosis.<BR>An active proliferation of epithelial lining cells was seen in cystic dilated ducts.<BR>Cholangiocarcinoma occurred in one rat on a basic diet for 40 weeks, after the cessation of 3'-Me-DAB for 4 weeks.<BR>The following three points have been discussed:<BR>1. The relation among oval cells, atypical epithelial cells, and epithelial lining cells of the duct in cholangiofibrosis.<BR>2. Irreversibility of the lesion of cholangiofibrosis.<BR>3. Possibility of histopathogenesis of cholangiocarcinoma arising from the epithelial lining cells of the duct in cholangiofibrosis.

収録刊行物

  • 肝臓

    肝臓 15 (5), 292-300, 1974

    一般社団法人　日本肝臓学会

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