Pegylated interferon-.ALPHA.2b and ribavirin combination therapy for pediatric patients with chronic hepatitis C

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  • Inui Ayano
    Division of Hepatology and Gastroenterology, Children's Center for Health and Development, Yokohama Eastern Hospital
  • Komatsu Haruki
    Division of Hepatology and Gastroenterology, Children's Center for Health and Development, Yokohama Eastern Hospital
  • Sogo Tsuyoshi
    Division of Hepatology and Gastroenterology, Children's Center for Health and Development, Yokohama Eastern Hospital
  • Hashimoto Takuji
    Division of Hepatology and Gastroenterology, Children's Center for Health and Development, Yokohama Eastern Hospital
  • Fujisawa Tomoo
    Division of Hepatology and Gastroenterology, Children's Center for Health and Development, Yokohama Eastern Hospital

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Other Title
  • 小児科領域におけるＣ型慢性肝炎に対するペグインターフェロンα２ｂ＋リバビリン併用療法の経験
  • ショウニカ リョウイキ ニ オケル Cガタ マンセイ カンエン ニ タイスル ペグインターフェロン アルファ 2b リバビリン ヘイヨウ リョウホウ ノ ケイケン
  • Pegylated interferon-α2b and ribavirin combination therapy for pediatric patients with chronic hepatitis C

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Abstract

Thirteen Japanese children and young adults (age range 10-40 years, median 18 years) with chronic hepatitis C have been treated with pegylated interferon α2b and ribavirin combination therapy in our pediatric center. The HCV RNA levels before treatment were 5-3,900 KIU/ml (median 1,500 KIU/ml), with HCV genotype 1 in 7 patients, 2a in 5, and 2b in 1. Of the 13 patients, 8 have completed the treatment course with sufficient follow-up to date, and 7 (with HCV genotype 1b in 4, 2a in 2 and 2b in 1) of them (88%) have achieved sustained virological response. The major adverse effect related to therapy was fever. This combination therapy was well tolerated in all the patients without cessation of the therapy. Our present results encourage treatment of pediatric hepatitis C patients with pegylated interferon and ribavirin, as in adult patients.<br>

Journal

  • Kanzo

    Kanzo 49 (8), 386-388, 2008

    The Japan Society of Hepatology

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