Choleresis induced by bucolome in guinea pigs

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  • KITANI Kenichi
    First Laboratory of Clinical Physiology, Tokyo Metropolitan Institute of Gerontology
  • KANAI Setsuko
    First Laboratory of Clinical Physiology, Tokyo Metropolitan Institute of Gerontology

Bibliographic Information

Other Title
  • ブコロームの利胆作用の検討-モルモット(guinea pig)
  • ブコローム ノ リタン サヨウ ノ ケントウ モルモット guinea pig
  • A study by erythritol clearance
  • のエリスリトールクリアランスに及ぼす影響

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Abstract

In order to examine the site of choleresis induced by bucolome, erythritol clearance was compared in guinea pigs before and after bucolome administration (20mg/100 g ip). The base-line bile flow rate in pentobarbital anesthetized guinea pigs was 24.00± 2.80μl/min/100g which was increased immediately after bucolome administration and reached the maximal flow rate of 41.66±5.03μl/min/100g 10min after bucolome administration.<BR>The canalicular bile flow rate as determined by erythritol clearance was 14.04± 1.41μl/min/100g before bucolome injection and increased to 27.63±4.24μl/min/100g by bucolome. The bucolome induced choleresis in guinea pigs was concluded to be of canaliular origin as was reported by the authors for rats and dogs.

Journal

  • Kanzo

    Kanzo 20 (1), 49-52, 1979

    The Japan Society of Hepatology

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