A case of liver cirrhosis C recovered from portal vein thrombosis developed during chemotherapy of pancreatic cancer with antithrombin-III and danaparoid sodium

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  • 膵癌術後化学療法中に門脈血栓症をきたし，アンチトロンビンＩＩＩ製剤，ｄａｎａｐａｒｏｉｄ　ｓｏｄｉｕｍ併用投与が奏効したＣ型肝硬変の１例
  • 症例報告 膵癌術後化学療法中に門脈血栓症をきたし,アンチトロンビン3製剤,danaparoid sodium併用投与が奏効したC型肝硬変の1例
  • ショウレイ ホウコク スイガン ジュツゴ カガク リョウホウ チュウ ニ モン ミャク ケッセンショウ オ キタシ アンチトロンビン 3 セイザイ danaparoid sodium ヘイヨウ トウヨ ガ ソウコウ シタ Cガタ カンコウヘン ノ 1レイ

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Description

A 75-year-old female with liver cirrhosis, type C, was referred to our hospital due to acute hepatic failure, which developed during chemotherapy of pancreatic tail cancer after the operation. Abdominal CT scan showed the thrombosis in the left branch of portal vein extending to the right branch and main trunk, and Child-Pugh score was 10 points, compatible with acute hepatic failure. Two weeks after we started administration of antithrombin-III and danaparoid sodium, the portal vein thrombosis disappeared, resulting in improvement of Child-Pugh score to 6 points at 1 month, with no adverse effects. The present case suggests that the administration of antithrombin-III and danaparoid sodium appeared to be safe and effective for the treatment of portal vein thrombosis associated with liver cirrhosis.<br>

Journal

  • Kanzo

    Kanzo 50 (7), 377-382, 2009

    The Japan Society of Hepatology

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