Experimental and Clinical Studies on the Effect of Urease Inhibitor on Hyperammoniemia

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Other Title
  • 高アンモニア血に対するウレアーゼ阻害剤の効果に関する実験的,臨床的研究
  • コウアンモニア チ ニ タイスル ウレアーゼ ソガイザイ ノ コウカ ニ カンスル ジッケンテキ , リンショウテキ ケンキュウ

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Description

In order to clarify the effect of urease inhibitor, acetohydroxamic acid (AHA), caprylohydroxamic acid (CHA) and nicotinohydroxamic acid (NHA) on hyperammoniemia, dogs with Eck fistula and rats with CCl4 hepatic damage associated with hyperammoniemia were use<BR>Clinically, oral administration of CHA was made in 8 cirrhotic patients with hyperammoniemia. The blood ammonia decreased significantly after the oral or intravenous administration of urease inhibitors in the experimental animals, and the decrease of blood ammonia was noted immediately after an intravenous administration. By the oral or intravenous administration of AHA or CHA in experimental rats, hyperammoniemia improved after the decrease of mucosal urease activities. The blood ammonia decreased in 5 out of 8 cirrhotic patients with hyperammoniemia. The effect of urease inhibitors on hyperammoniemia is thought to be systemic and to be brought about by the inhibition of intestinal mucosal urease activities.

Journal

  • Kanzo

    Kanzo 15 (3), 172-185, 1974

    The Japan Society of Hepatology

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