Diagnostic significance of Lecithin: Cholesterol Acyltransferase activity in liver diseases

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  • MURAWAKI Yoshikazu
    The second department of internal medicine, Tottori University School of Medicine
  • HORIE Yutaka
    The second department of internal medicine, Tottori University School of Medicine
  • YAMANISHI Yasuhito
    The second department of internal medicine, Tottori University School of Medicine
  • KAWASAKI Hironaka
    The second department of internal medicine, Tottori University School of Medicine
  • HIRAYAMA Chisato
    The second department of internal medicine, Tottori University School of Medicine

Bibliographic Information

Other Title
  • 肝疾患におけるLecithin: Cholesterol Acyltransferaseの診断的意義
  • カン シッカン ニ オケル Lecithin Cholesterol Acyl

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Abstract

Lecithin: plasma cholesterol acyltransferase (LCAT) activity was measured in 40 patients with liver diseases by the change in cholesterol concentration after incubation of the plasma with a lecithin sol. The normal level of LCAT activity was found to be 93±17nmol/ml/hr. LCAT activity was lowered in patients with acute and chronic liver disease. LCAT activity decreased parallel with the severity of hepatocellular injury and more sensitively than serum levels of cholinesterase and/or albumin. LCAT activity was depressed by glycocholate addition in vitro over the concentration of 200μM.

Journal

  • Kanzo

    Kanzo 19 (5), 464-470, 1978

    The Japan Society of Hepatology

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