Histopathologic study of hepatocellular carcinoma in relation to liver cirrhosis and hepatitis B virus

  • UCHIDA Toshikazu
    First Department of Pathology, Nihon University School of Medicine
  • SHIKATA Toshio
    First Department of Pathology, Nihon University School of Medicine
  • KANEDA Haruo
    Third Department of Medicine, Nihon University School of Medicine

Bibliographic Information

Other Title
  • 肝細胞癌の組織像と非癌部病変及びHBウイルス感染の有無との関係
  • カン サイボウ ガン ノ ソシキゾウ ト ヒ ガン ブ ビョウヘン オヨビ H

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Abstract

Histologic features of hepatocellular carcinoma were studied in autopsy cases of 84 patients, in relation to complication of liver cirrhosis and presence or absence of hepatitis B virus (HBV) infection.<BR>Hepatocellular carcinoma was well divided histologically according to their pure morphological patterns, into two major categories: Common (trabecular or trabeculotubular) type and special type.<BR>The presence or absence of infection of HBV was examined by orcein or other stains for hepatitis B surface antigen in tissue sections.<BR>As a result, 72 (86%) cases revealed common type and 12 (14%) cases special type; 24 (29%)cases showed HBV-positivity; the incidence of HBV-positivity of common type was 32%, while that of special type 8%.<BR>Characteristically, almost all carcinomas associated with HBV-positivity, except for one case, revealed common type. All carcinomas with special type but without cirrhosis were HBV-negative. HBV might be rather related to common type hepatocellular carcinoma than special type.

Journal

  • Kanzo

    Kanzo 19 (11), 1063-1076, 1978

    The Japan Society of Hepatology

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