Familially Observed Delay in Clearance of Plasma Indocyanine Green

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Other Title
  • 家族的に発現した血中ICG消失の遅延に関する研究
  • カゾクテキ ニ ハツゲンシタ ケッチュウ ICG ショウシツ ノ チエン ニカ
  • Part III: Further Studies on the Trait, its Incidence and Mode of Transmission
  • 第3部 第2家系の研究ならびに本症の発生頻度と遺伝様式の検討

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Description

Electron microscopic studies on 3 subjects with FDIC in an additional kindred involving 7 subjects with the trait revealed that they were not concordant with those observed in the previously reported kindred. KICG values in the kindred were distributed trimodally. Although the kindred was highly inbred, the 7 subjects with the trait were off- springs of seemingly non-consanguineous parents. These results suggested an incompletely dominant inheritance or an intervention of modifier genes in the transmission of the trait in the additional kindred and genetic heterogeneity in FDIC was postulated. The incidence of the subjects with FDIC was estimated approximately 0.4% in Tsushima district.

Journal

  • Kanzo

    Kanzo 16 (7), 441-447, 1975

    The Japan Society of Hepatology

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