Ischemic colitis induced on the injection day of pegylated-interferon for persistently normal ALT

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  • Aoki Yoshihiko
    The Research Center for Hepatitis & Immunology, Kohnodai Hospital, National Center for Global Health and Medicine
  • Murata Kazumoto
    The Research Center for Hepatitis & Immunology, Kohnodai Hospital, National Center for Global Health and Medicine
  • Saito Hiroaki
    The Research Center for Hepatitis & Immunology, Kohnodai Hospital, National Center for Global Health and Medicine
  • Matsui Teppei
    The Research Center for Hepatitis & Immunology, Kohnodai Hospital, National Center for Global Health and Medicine
  • Ito Kiyoaki
    The Research Center for Hepatitis & Immunology, Kohnodai Hospital, National Center for Global Health and Medicine
  • Imamura Masatoshi
    The Research Center for Hepatitis & Immunology, Kohnodai Hospital, National Center for Global Health and Medicine
  • Masaki Naohiko
    The Research Center for Hepatitis & Immunology, Kohnodai Hospital, National Center for Global Health and Medicine
  • Kobayashi Masanori
    Division of Gastroenterology, Kohnodai Hospital, National Center for Global Health and Medicine
  • Aoki Yoichiro
    Division of Gastroenterology, Kohnodai Hospital, National Center for Global Health and Medicine
  • Ogami Toshiko
    Division of Gastroenterology, Kohnodai Hospital, National Center for Global Health and Medicine
  • Nishimura Takashi
    Division of Gastroenterology, Kohnodai Hospital, National Center for Global Health and Medicine
  • Yada Tomoyuki
    Division of Gastroenterology, Kohnodai Hospital, National Center for Global Health and Medicine
  • Yoshizawa Dai
    Division of Gastroenterology, Kohnodai Hospital, National Center for Global Health and Medicine
  • Koizuka Hitohiko
    Division of Gastroenterology, Kohnodai Hospital, National Center for Global Health and Medicine
  • Uemura Naomi
    Division of Gastroenterology, Kohnodai Hospital, National Center for Global Health and Medicine
  • Mizokami Masashi
    The Research Center for Hepatitis & Immunology, Kohnodai Hospital, National Center for Global Health and Medicine

Bibliographic Information

Other Title
  • ペグインターフェロン投与当日に虚血性大腸炎が出現したｐｅｒｓｉｓｔｅｎｔｌｙ　ｎｏｒｍａｌ　ＡＬＴ（ＰＮＡＬＴ）の１例
  • 症例報告 ペグインターフェロン投与当日に虚血性大腸炎が出現したpersistently normal ALT(PNALT)の1例
  • ショウレイ ホウコク ペグインターフェロン トウヨ トウジツ ニ キョケツセイ ダイチョウエン ガ シュツゲン シタ persistently normal ALT(PNALT)ノ 1レイ

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Abstract

Various adverse effects by pegylated-interferon/Ribavirin (Peg-IFN+RBV) therapy have been reported. A 47 year-old female without a history of hypertension or diabetes mellitus had left lower abdominal pain on the first day of Peg-IFN+RBV therapy for persistently normal ALT (PNALT) with spontaneous relief. On the second injection day of Peg-IFN, she experienced stronger pain in the same lesion with hematochezia. Colonoscopy revealed 3 lines of longitudinal ulcerations in her descending colon, compatible with ischemic colitis. Her symptom was disappeared after cessation of Peg-IFN+RBV. This case could be interesting because close causal relationship between Peg-IFN and ischemic colitis was observed although there are some reports of ischemic colitis several months after IFN injection.<br>

Journal

  • Kanzo

    Kanzo 52 (12), 765-769, 2011

    The Japan Society of Hepatology

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