Spread of HB Virus in the Household

KOJIMA Mineo, FUKUDA Nobuomi, KAWAI Fukiko, HIROSE Hiroshi, OSHIMA Kenjiro, KOBAYASHI Shigeyoshi, TAKAHASHI Yoshiyata, ADACHI Nobuyuki, MAYUMI Makoto

doi:10.2957/kanzo.19.250

A survey of hepatitis type B infection was performed on sixteen familiies, each of which included at least one patient with acute type B viral hepatitis admitted to Gifu Prefectural Gifu Hospital from July 1975 to July 1977. We examined their sera for HBsAg, anti -HBs, HBeAg, anti -HBe, anti -HBc and subtype more than two times. The examination was made within one week of admission of the index cases, and again at least four weeks there after. The families under the investigation consisted of one couple without offsprings and fifteen couples, each living with their offsprings. None of the spouses of the index was a HBsAg chronic carrier, but five of the married couples had suffered from acute hepatitis B about four months after the onset of the illness of the index spouse. On the other hand, among twenty eight children of fifteen families, thirteen children (46%) of twelve families (80%) were at the first examination HBsAg, HBeAg and anti-HBc (high titer of 2, IAHA) positive.<BR>Their age was between one year three months and six years old, especially eleven of the thirteen children with HBsAg were younger than three years old. Besides, all of them were found to be chronic HBsAg carriers. In all the families, the subtype of the index cases was the same as that of their HBsAg positive children. The subtype was adw except one case of adr. In this study the majority of patients with adult acut hepatits B are suspected to be infected from their HBsAg carrier son and/or daughter who had been infected perhaps in a hospital by parenteral route.

Spread of HB Virus in the Household

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