Lecithin: cholesterol acyltransferase activities in liver diseases

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  • IWASAKI Yasuhiko
    The Third Department of Internal Medicine, Faculty of Medicine. University of Tokyo
  • AKANUMA Yasuo
    The Third Department of Internal Medicine, Faculty of Medicine. University of Tokyo
  • YOKOYAMA Shinji
    The Third Department of Internal Medicine, Faculty of Medicine. University of Tokyo
  • OHKUBO Akiyuki
    The Third Department of Internal Medicine, Faculty of Medicine. University of Tokyo
  • KOSAKA Kinori
    The Third Department of Internal Medicine, Faculty of Medicine. University of Tokyo

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Other Title
  • 肝疾患におけるLecithin: Cholesterol Acyltransferase活性
  • カン シッカン ニ オケル Lecithin Cholesterol Acyl
  • Its relationship to cholesterol in high density lipoproteins
  • 特にHigh Density Lipoproteinコレステロールとの関係

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Abstract

Plasma LCAT activities were determined in patients with chronic liver diseases and in normal controls, by measurement of plasma cholesterol esterification during 2 hours' incubation with dipalmitoyl lecithin sols. In cirrhotics, plasma LCAT activities were reduced and the values were significantly correlated with the ratios of esterified cholesterol to total cholesterol (CE ratio) both in plasma and in HDL. The ratios of total cholesterol present in HDL to that in plasma were not significantly different between cirrhotics and controls. Highly significant correlation of LCAT activities to serum albumin levels, prothrombin time and ICG excretion were found in cirrhotics.<BR>These findings support that in cirrhotics, decreases in both esterified cholesterol levels and CE ratios were mainly due to a reduction of plasma LCAT activities. Futhermore this reduction of LCAT activities was supposed to be related to a decrease in functional liver mass, which was demonstrated by the reduction of ICG excretion.

Journal

  • Kanzo

    Kanzo 19 (4), 354-361, 1978

    The Japan Society of Hepatology

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