ICG Rmaxによる肝細胞機能総量判定の臨床的意義について

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  • Clinical significance of ICG Rmax measurement for quantitation of the total functioning hepatic cell mass
  • ICG Rmax ニヨル カン サイボウ キノウ ソウリョウ ハンテイ ノ リ

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ICG Rmax was measured in 207 patients with various liver diseases to quantitate the total functioning hepatic cell mass. Simplification of the method for measurement of ICG Rmax was also studied for routine clinical use. The most reliable value of ICG Rmax was obtained by the method loaded with three dose (0.5, 2.0 and 5.0mg/kg B.W.). However, two dose loading (0.5 and 5.0mg/kg B.W.) also revealed a reliable result suggesting usefulness as a routine test.<BR>ICG Rmax decreased significantly in various liver diseases. Especially in liver cirrhosis, the decrease was prominent. The differences of ICG Rmax between acute and convalescent stage of acute hepatitis, and between compensated and decompensated liver cirrhosis were statistically significant, respectively. In liver cirrhosis, fatal cases by hepatic failure showed significantly lower ICG Rmax than survived cases, or dead cases by the other causes. ICG Rmax showed significantly higher incidence of abnormal value than the other ICG clearance tests in acute and chronic hepatitis but not in cirrhosis and primary hepatoma.<BR>These results suggested that ICG Rmax well reflects the changes in the total functioning hepatic cell mass, and is a useful parameter for analysis of pathophysiology of liver diseases, which can not be evaluated by the other liver function tests.

収録刊行物

  • 肝臓

    肝臓 21 (12), 1614-1625, 1980

    一般社団法人　日本肝臓学会

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