Studies on the clinical significance of oral galactose tolerance test

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  • HAYASHI Taizo
    Osaka Medical College, Central Laboratory for Clinical Investigations
  • NAGAI Shinichiro
    Osaka Medical College, Central Laboratory for Clinical Investigations
  • MISUGI Yoshikiyo
    Osaka Medical College, Central Laboratory for Clinical Investigations
  • TABA Shigeki
    Osaka Medical College, Central Laboratory for Clinical Investigations

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Other Title
  • ガラクトース経口負荷試験の意義に関する臨床的研究
  • ガラクトース ケイコウ フカ シケン ノ イギ ニ カンスル リンショウテキ

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Abstract

Changes of blood lactate and pyruvate after 40g oral galactose tolerance test were examined in the healthy subjects and the patients with liver diseases and with diabetes. The findings of galactose tolerance test were classified 3 groups by the our standard previously reported, namely normal, moderate abnormal and far abnormal group.<BR>In the normal group, a transient significant elevations of blood lactate were observed after the loading. Blood pyruvate showed a transient increase such as lactate in both the healthy subjects and diabetics, but no significant changes in the liver diseases. In the moderate and far abnormal groups, the elevation of blood lactate and pyruvate diminished in order, and the peaks of these elevations deiayed compared with the normal group. After galactose loading the significant positive correlations between lactate and pyruvate were observed in healthy subjects and diabetics, but no correlation in the liver diseases. Contrary to the relationship of lactate and pyruvate, the significant negative correlations between lactate and NEFA were observed only in the abnormal groups after the loading.

Journal

  • Kanzo

    Kanzo 19 (1), 58-66, 1978

    The Japan Society of Hepatology

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