A Case of Pleuropulmonary Blastoma That Developed Into Adenomatous Goiter After Multimodal Treatment Including High-Dose Chemotherapy With Peripheral Blood Stem Cell Transplantation
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- Ohno Sachie
- Department of Pediatric Surgery, Graduate School of Medicine, Chiba University
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- Hishiki Tomoro
- Department of Pediatric Surgery, Chiba Children’s Hospital
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- Saito Takeshi
- Department of Pediatric Surgery, Graduate School of Medicine, Chiba University
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- Terui Keita
- Department of Pediatric Surgery, Graduate School of Medicine, Chiba University
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- Mitsunaga Tetsuya
- Department of Pediatric Surgery, Graduate School of Medicine, Chiba University
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- Nakata Mitsuyuki
- Department of Pediatric Surgery, Graduate School of Medicine, Chiba University
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- Mise Naoko
- Department of Pediatric Surgery, Graduate School of Medicine, Chiba University
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- Oita Satoru
- Department of Pediatric Surgery, Graduate School of Medicine, Chiba University
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- Yoshida Hideo
- Department of Pediatric Surgery, Graduate School of Medicine, Chiba University
Bibliographic Information
- Other Title
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- 末梢血幹細胞移植を併用した大量化学療法を含む集学的治療施行後,腺腫様甲状腺腫を発症した胸膜肺芽腫の1例
- 症例報告 末梢血幹細胞移植を併用した大量化学療法を含む集学的治療施行後,腺腫様甲状腺腫を発症した胸膜肺芽腫の1例
- ショウレイ ホウコク マッショウケツ カンサイボウ イショク オ ヘイヨウ シタ タイリョウ カガク リョウホウ オ フクム シュウガクテキ チリョウ シコウ ゴ,セン シュ ヨウ コウジョウセンシュ オ ハッショウ シタ キョウマク ハイ ガ シュ ノ 1レイ
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Abstract
Pleuropulmonary blastoma (PPB) is a rare neoplasm originating from intrathoracic mesenchymal tissue that usually affects children under 5 years of age. Here, we present a case of PPB that developed into adenomatous goiter after the complete response of PPB. A 2-year-old girl presenting with left chest pain and fever was referred to our hospital. Chest radiography and computed tomography scan images showed a large solid mass in the left hemithorax. Excisional biopsy of the mass was diagnostic of PPB (type II). Metastatic work-up showed negative findings. Chemotherapy produced a partial response, and radical tumor resection was performed. After surgery, high-dose chemotherapy followed by peripheral blood stem cell transplantation was applied and reimaging showed no evidence of the disease. Forty months after the completion of therapy, she presented with multiple thyroid nodules in both lobes. She underwent a subtotal thyroidectomy; however, residual thyroid tissue was found to have developed multiple nodules. Two years later, the size of nodules had increased and a total thyroidectomy was carried out. Histopathologic examination showed adenomatous goiter, which was the same diagnosis as in the previous thyroidectomy. She remained without clinical evidence of recurrence for 7 years after the initial diagnosis.
Journal
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- Journal of the Japanese Society of Pediatric Surgeons
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Journal of the Japanese Society of Pediatric Surgeons 51 (7), 1190-1197, 2015
The Japanese Society of Pediatric Surgeons
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Details 詳細情報について
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- CRID
- 1390001204798505728
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- NII Article ID
- 130005114217
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- NII Book ID
- AN00192281
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- ISSN
- 21874247
- 0288609X
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- NDL BIB ID
- 027015903
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- CiNii Articles
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- Abstract License Flag
- Disallowed