Stimmulating effect on sebum secretion of γ-oryzanol ointment and its application to several skin diseases

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Other Title
  • γ-オリザノール配合軟膏の臨床効果の検討
  • ガンマ オリザノール ハイゴウ ナンコウ ノ リンショウ コウカ ノ ケントウ
  • 皮脂分泌促進作用, パッチテストおよび基剤との比較臨床試験結果

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Abstract

The stimulating effect on sebaceous secretion of The stimulating effect on sebaceous secretion of γ-oryzanol ointment (IKD-γ), which was topically applied on the volar aspect of 40 volunteers, was evaluated by the double blind half side method. The stimulating effect was observed in a 1 or 2% IKD-γ but not in a 0.1% IKD-γ. No significant difference was proved between 1 and 2% concentration of IKD-γ.<BR>Patch test of IKD-γ was performed in 65 volunteers and 37 out-patients of the dermatological clinic of Branch Hospital of the Nagoya University. Positive rates of the patch test and irritating index were low.<BR>With double blind test IKD-γ was found to be slightly more effective on xerosis and ichtyosis than its vehicle alone. Side effects of IKD-γ were rare. The drug was evaluated to be useful in the treatment of the diseases with dry skin.

Journal

  • Skin research

    Skin research 21 (2), 123-134, 1979

    Meeting of Osaka Dermatological Association

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