Expression Patterns of the Genes Related to Neuronal Differentiation and Stratification of Patients' Prognosis in Stage 4 Neuroblastomas
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- Matsunaga Tadashi
- Department of Pediatric Surgery, Chiba Graduate University
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- Terui Elena
- Department of Pediatric Surgery, Chiba Graduate University
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- Yoshida Hideo
- Department of Pediatric Surgery, Chiba Graduate University
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- Kouchi Katsunori
- Department of Pediatric Surgery, Chiba Graduate University
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- Kuroda Hiroaki
- Department of Pediatric Surgery, Chiba Graduate University
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- Hishiki Tomoro
- Department of Pediatric Surgery, Chiba Graduate University
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- Yamada Shinichi
- Department of Pediatric Surgery, Chiba Graduate University
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- Kawamura Kenji
- Division of Pediatric Surgery, Matsudo Municipal Hospital
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- Etoh Takao
- Division of Pediatric Surgery, Chiba Children's Hospital
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- Ohnuma Naomi
- Department of Pediatric Surgery, Chiba Graduate University
Bibliographic Information
- Other Title
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- Stage 4神経芽腫における分化関連遺伝子(trk A, trk B, c-srcN2)の発現様式と予後層別化に関する検討
- Stage4 シンケイ ガ シュ ニ オケル ブンカ カンレン イデンシ trkA trkB c srcN2 ノ ハツゲン ヨウシキ ト ヨゴソウ ベツカ ニ カンスル ケントウ
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Description
Purpose : The prognosis of the patients with stage 4 neuroblastomas found by clinical symptoms is very poor in spite of recent advances in multimodal treatment. We analyzed expression of genes related to neuronal differentiation in these tumors. Stratification of prognosis of such patients and future therapeutic approach are discussed in this paper. Materials and Methods : Genomic amplification of the N-myc gene was analyzed by Southern blot hybridization and expression of trk A, trk B, and src gene was analyzed by semi-quantitative RT-PCR in 24 clinically detected neuroblastomas at stage 4. Results : The patients having tumors with amplified N-myc, or low expression of trk A, or expression of trk B tended to die in a shorter period, but this tendency was not statistically significant. On the other hand, the tumors with high expression of c-srcN2 had significantly better prognosis. The tumors with amplified N-myc and expression of trk B were resistant to chemotherapy and most patients with those tumors died within 12 months after diagnosis. The prognosis of the patients having tumors with a single copy of N-myc and high expression of c-srcN2 was excellent, as they responded well to chemotherapy. There was a high rate of recurrence after complete remission in the tumors with amplified N-myc and no expression of trk B, and the tumors with a single copy of N-myc and low expression of c-srcN2. Conclusion : Analyses for amplification and expression of genes related to neuronal differentiation enabled stratification of the prognosis of the patients with stage 4 neuroblastomas. A new therapeutic approach is necessary against the tumors that are expected not to respond to chemotherapy or to recur after complete remission.
Journal
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- Journal of the Japanese Society of Pediatric Surgeons
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Journal of the Japanese Society of Pediatric Surgeons 41 (1), 1-8, 2005
The Japanese Society of Pediatric Surgeons
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Details 詳細情報について
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- CRID
- 1390001204822899072
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- NII Article ID
- 110002120447
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- NII Book ID
- AN00192281
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- ISSN
- 21874247
- 0288609X
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- NDL BIB ID
- 7260652
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- CiNii Articles
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- Abstract License Flag
- Disallowed