Role of the β-Adrenoreceptor in the Morphine-Induced Inhibition of Colonic Motility

DOI Web Site 11 References
  • Naito Michiko
    Department of Pediatric Surgery, Showa University Hospital:Department of Physiology, Showa University School of Medicine
  • Hisamitsu Tadashi
    Department of Physiology, Showa University School of Medicine
  • Umezawa Teruyasu
    Department of Physiology, Showa University School of Medicine
  • Toki Akira
    Department of Pediatric Surgery, Showa University Hospital
  • Yatsuzuka Masashi
    Department of Pediatric Surgery, Showa University Hospital
  • Suzuki Junichi
    Department of Pediatric Surgery, Showa University Hospital
  • Suzuki Koumei
    Department of Pediatric Surgery, Showa University Hospital
  • Watanabe Rie
    Department of Pediatric Surgery, Showa University Hospital

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  • Morphineによる大腸運動抑制に対するβアドレナリン受容体の役割について
  • Morphine ニ ヨル ダイチョウ ウンドウ ヨクセイ ニ タイスル ベータ アドレナリン ジュヨウタイ ノ ヤクワリ ニ ツイテ

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Abstract

Purpose: Constipation is one of the major side effects of the potent analgesic opioids. It is known that the opioid activates the central adrenergic neuron system and plays an important role in opioid-induced analgesia. But the role of the adrenergic system in the morphine-induced depression of colonic motility has not been clarified. Thus we examined the effect of β-adrenergic antagonists on the morphine-induced inhibition of colonic motility in rats. Methods: Male Wistar rats (250-350g) were anesthetized by urethane and α-chloralose (ip). The left femoral vein was catheterized for intravenous injections. The colonic motility was monitored through a balloon catheter connected to a transducer, which was inserted into the rat's colon 4cm from the anus. Each β-adrenergic antagonist was administered (iv) 5 min before morphine injection. Results: Morphine (100μg/kg) depressed colonic motility for 33 min. The administration of the nonselective β-adrenoreceptor antagonist propranolol (20μg/kg) and the β_1-adrenoreceptor antagonist atenolol (20μg/kg) significantly reduced the depression of the colonic motility, while β_2-adrenoreceptor antagonist ICI 118,551 hydrochloride (20μg/kg) produced little effect. Conclusions: The results suggested that morphine inhibits colonic motility by the activation of the adrenergic system, especially through the β_1-adrenergic system.

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