Effects of the Herbal Medicine Rikkunshi-to on Small Intestinal Motility

DOI Web Site 1 Citations 27 References
  • Ohashi Yusuke
    The Pediatric Surgery Services, Showa University School of Medicine:Children's Medical Center, Showa University Northern Yokohama Hospital
  • Chiba Masahiro
    The Pediatric Surgery Services, Showa University School of Medicine:Department of Surgery, Showa University Fujigaoka Hospital
  • Kawano Shinya
    The Pediatric Surgery Services, Showa University School of Medicine:Department of Surgery, Showa University Fujigaoka Hospital
  • Gomi Akira
    The Pediatric Surgery Services, Showa University School of Medicine:Children's Medical Center, Showa University Northern Yokohama Hospital
  • Sugiyama Akihide
    The Pediatric Surgery Services, Showa University School of Medicine:Children's Medical Center, Showa University Northern Yokohama Hospital
  • Toki Akira
    The Pediatric Surgery Services, Showa University School of Medicine:Department of Pediatric Surgery, Showa University School of Medicine
  • Yatsuzuka Masashi
    The Pediatric Surgery Services, Showa University School of Medicine:Department of Pediatric Surgery, Showa University School of Medicine
  • Sanada Yutaka
    The Pediatric Surgery Services, Showa University School of Medicine:Department of Surgery, Showa University Fujigaoka Hospital

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Other Title
  • 上部消化管運動に対する六君子湯の効果
  • ジョウブ ショウカカン ウンドウ ニ タイスル リックンシトウ ノ コウカ

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Abstract

Purpose: Rikkunshi-to has been widely prescribed for patients with functional dyspepsia. However, its pharmacological actions on intestinal motility are still unknown. This study was conducted to evaluate the effects of Rikkunshi-to on small intestinal motility. Methods: Male Wistar rats weighing 220-260 grams were used. All experiments were performed after 8 hours of fasting. 1) The small intestinal transit rate was measured after the administration of Rikkunshi-to. 2) Male Wistar rats were equipped with force transducers on the stomach, duodenum, and proximal jejunum. Contractile motor activity of the bowel in the interdigestive state was measured following the administration of Rikkunshi-to. 3) The serum gastrin levels and nitrite and nitrate (NOx) levels at the portal vein were also determined. Results: 1) The small intestinal transit rate was significantly inhibited after administration of Rikkunshi-to. 2) Rikkunshi-to (0.3-0.7g/kgBW) obviously reduced the motility index in the duodenum and jejunum in a dose-dependent manner. 3) Both the serum gastrin and NOx levels were significantly increased 30min after the administration of Rikkunshi-to. While the increase of NOx levels was maintained, the gastrin levels returned to the control level after 60min. Conclusion: These results indicate that Rikkunshi-to inhibits small intestinal movement. The mechanism of its inhibition seems to be related to the relaxation of intestinal smooth muscle by nitric oxide. Oral administration of Rikkunshi-to prior to feeding is likely to be useful for extending the retention time of food in the small intestine.

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