Melt Spinning of Poly (caprolacton)/Drag Blends and Drag Lerease Behavior from Blend Fibers.

DOI Web Site
  • Yamane Hideki
    Division of Advanced Fibro Science, Graduate School, Kyoto Institute of Technology
  • Inoue Aya
    Department of Polymer Science and Engineering, Kyoto Institute of Technology
  • Koike Mitsuko
    Department of Polymer Science and Engineering, Kyoto Institute of Technology
  • Takahashi Masaoki
    Department of Polymer Science and Engineering, Kyoto Institute of Technology
  • Igaki Keiji
    Igaki Medical Planning Co. Ltd.

Bibliographic Information

Other Title
  • 薬剤含有ポリカプロラクトンの繊維化と薬剤放出挙動

Abstract

Tranilast, N- (3, 4-dimethoxycinnamoyl) anthranilic acid), which suppresses the fibro blast hyperpalsia, and poly (ε-caprolactone) (PCL), a biodegradable polyester with a low melting point, were blended and melt spun to produce the drug releasing biodegradable fibers.<br>Thermal analyses, polarized optical microscope observation, and WAXD analyses revealed that tranilast existed as crystal in PCL solid at room temperature and dissolved in molten PCL at an elevated temperature. This tranilast acted either as a crystal nucleating agent or an impurity which obstracted the crystallization of PCL depending on the tranilast content and the thermal history.<br>Melt-spun fibers of PCL/tranilast blends had mechanical properties which deteriorated with increasing tranilast contents. The drug release rate decreased with increasing draw ratio. This seems to be attributable to high crystallinity of drawn fibers.

Journal

  • Sen'i Gakkaishi

    Sen'i Gakkaishi 55 (6), 261-266, 1999

    The Society of Fiber Science and Technology, Japan

Keywords

Details 詳細情報について

Report a problem

Back to top