ACUPUNCTURE AND MORPHINE ANALGESIA INHIBITORY SYSTEM IN THE LATERAL CENTROMEDIAN NUCLEUS OF THE THALAMUS
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- MERA Hitoshi
- Department of Physiology, School of Medicine, Showa University
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- KOBORI Masao
- Department of Physiology, School of Medicine, Showa University
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- TAKESHIGE Chifuyu
- Department of Physiology, School of Medicine, Showa University
Bibliographic Information
- Other Title
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- 針, モルヒネ鎮痛抑制系
- ハリ モルヒネ チンツウ ヨクセイケイ
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Abstract
Acupuncture (AA), 0.5 mg/kg morphine (MA) and the dorsal periaqueduct central gray stimulation-produced (d-PAG-SPA) analgesia measured by rat tail-flick latency were augmented by lesion of the lateral centromedian nucleus of the thalamus (1-CM) .The augmentation of analgesia was prominent in acupuncture non-effective animals. Abolished AA and MA by lesion of the posterior, lateral hypothalamus, the lateral septum, cingulate bundle, dorsal hippocampus, habenulo-interpeduncular tract or the medial centromedian nucleus of thalamus reappeared as slightly larger analgesia than control after lesion of 1-CM, while abolished AA and MA by lesion of the d-PAG, anterior hypothalamus or hypophysectomy did not reappear after lesion of the 1-CM. Therefore, two acupuncture afferent pathways were recognized: one (R1) is inhibited by 1-CM and the other (R2) is not inhibited by 1-CM. The stimulation of 1-CM completely abolished AA, MA and d-PAG-SPA during stimulation in the R2-lesioned animals, while being partially inhibited in the presence of R1 and R2 pathways. Evoked potentials were not recorded from 1-CM by acupuncture stimulation and stimulation of 1-CM did not influence on tail-flick latency.
Journal
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- Journal of The Showa Medical Association
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Journal of The Showa Medical Association 41 (6), 629-640, 1981
The Showa University Society
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Details 詳細情報について
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- CRID
- 1390001204834873600
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- NII Article ID
- 130001825019
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- NII Book ID
- AN00117027
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- ISSN
- 21850976
- 00374342
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- NDL BIB ID
- 2478158
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- Data Source
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- JaLC
- NDL
- CiNii Articles
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- Abstract License Flag
- Disallowed