IMMUNOHISTOCHEMICAL STUDY OF GLOMERULAR CHANGE IN MINIMAL CHANGE NEPHROTIC SYNDROME AND FOCAL SEGMENEAL GLOMERULOSCLEROSIS ON THE RESPONSIVENESS OF STEROID TREATMENT

DOI Web Site

Bibliographic Information

Other Title
  • 微小変化群と巣状系球体硬化症における上皮細胞骨格 (Synaptopodin) と系球体接着因子 (α-dystroglycan) とステロイド療法に関する研究
  • 微小変化群と巣状糸球体硬化症における上皮細胞骨格(Synaptopodin)と糸球体接着因子(α-dystroglycan)とステロイド療法に関する研究
  • ビショウ ヘンカグン ト ソウジョウ シキュウタイ コウカショウ ニ オケル ジョウヒ サイボウ コッカク Synaptopodin ト シキュウタイ セッチャク インシ アルファ dystroglycan ト ステロイド リョウホウ ニ カンスル ケンキュウ

Search this article

Abstract

The aim of this study was to analyse more precisely a prototype of nephrotic syndrome, such as minimal change nephrotic syndrome (MCNS) and focal segmental glomerulosclerosis (FSGS) not only clinically and pathologically including light (LM), immunof luorescence (IF), electron microscopical (EM) findings, but also by studying the expression of synaptopodin (SYN) and α dystroglysan (ADG) in the glomeruli on the aspects of responsiveness of steroid puls treatment. Renal biopsy specimens obtained from patients with MCNS (n=8) and FSGS (n12) were divided into responder group (R) and non-responder group (NR) . A significant difference between R (n=3) and NR (n=5) in MCNS was found : not to be present in clinical and LM findings, to be increased in podocyte vacuolation in NR, not to be present in podocyte detachment in both groups, not to be reduced of SYN staining in both groups and to be reduced of ADG staining in NR. A significant difference between R (n=4) and NR (n=8) in FSGS was found : not to be present in clinical findings, not to be present in glomerular sclerosis in both groups, to be increased in glomerular adhesion in NR, not to be present in tubulointerstitial injury in both groups, not to be present in podocyte-vacuolation and -detachment in both groups, to be reducted in glomerular SYN staining in NR and to be reducted in glomerular ADG staining in R. No peculiar IF findings were observed in MCNS and FSGS. These results suggest that the strategy of treatment, such as steroid hormone and immunosuppressant agents, should be proceeded by evaluation according not only of the LM and EM findings, but also of the immunohistochemical study such as both SYN and ADG stainings.

Journal

Keywords

Details 詳細情報について

Report a problem

Back to top