EXPERIMENTAL STUDY OF REGENERATED CILIATED CELLS WHEN AN ARTIFICIAL TRACHEN IS REBUILT USING COLLAGEN

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  • コラーゲン人工気管再建における線毛上皮の再生に関する研究
  • コラーゲン ジンコウキカン サイケン ニ オケル センモウ ジョウヒ ノ サイセイ ニ カンスル ケンキュウ

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In the field of head and neck surgery, when a trachea is removed in a large area, reconstruction of the trachea using an artificial trachea is carried out. One characteristic of this collagen is that the mucous membrane regenerates. We researched histologically and electoronmicroscopically cellular regeneration when an artificial trachea is rebuilt using the collagen of a rabbit. The rabbit was anesthetized and its trachea was exposed. We operated on the tracheal incision, 5 mm×10mm in size. Subsequently, a large amount of collagen was fixed on a collagen sheet. Collagen fibers were observed on the collagen sheet in the extraction trachea after one week. The surface of the collagen sheet was not covered with ciliated epithelium. Connective tissues were made on the collagen sheet after two weeks. Basal membranes, basal cells and ciliated cell were extended from the trachea incision side of the connective tissue. After three weeks, ciliated cells and brush cells were observed on the collagen sheet. Four weeks after transplantation, the surface of the collagen sheet was covered with ciliated epithelium, and the tracheal structure was nearly normal. The collagen sheet gradually dissolved, was absorbed, and in the 12th week put on the connective tissue. The collagen sheet we developed may be an effective method to reconstruct an artificial trachea.

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