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- NAGATA Masakazu
- Department of Urology, Showa University School of Medicine
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- FUKAGAI Takashi
- Department of Urology, Showa University School of Medicine
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- IAGARASHI Atsushi
- Department of Urology, Showa University School of Medicine
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- SUZUKI Kota
- Department of Urology, Showa University School of Medicine
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- MORITA Masashi
- Department of Urology, Showa University School of Medicine
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- MASUYAMA Tsuneo
- Department of Urology, Showa University School of Medicine
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- YOSHIDA Hideki
- Department of Urology, Showa University School of Medicine
Bibliographic Information
- Other Title
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- 未治療前立腺癌患者における骨動態の検討
- 未治療前立腺癌患者における骨動態の検討--骨密度と骨代謝マーカーについて
- ミチリョウ ゼンリツセン ガン カンジャ ニ オケル コツ ドウタイ ノ ケントウ コツミツド ト コツ タイシャ マーカー ニ ツイテ
- ―骨密度と骨代謝マーカーについて―
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Abstract
Androgen deprivation therapy (ADT) decreases bone mineral density (BMD) and increases the risk of fracture in men with prostate cancer. Smith has stated that prostate cancer patients show a degradation of BMD prior to ADT. We, therefore, studied the bone dynamics in Japanese prostate cancer patients prior toADT. BMD of the total hip, femoral neck, lumbar spine and forearm were measured by dual-energy x-ray absorptiometry (DEXA) before treatment in 53 prostate cancer patients without bone metastasis and in 16 patients with bone metastasis. Bone metabolism measurements of serum NTX and serum BAP were also carried out before treatment in 62 prostate cancer patients without bone metastasis and 22 patients with bone metastasis. Measurements in the total hip of nine of the 53 patients without bone metastasis indicated osteoporosis. Measurements of the femoral neck in eleven of the 53 patients indicated osteoporosis. Results show that Japanese prostate cancer patients without bone metastasis do not suffer from bone density degradation prior to ADT; only the Z score of the forearm showed a minus value. Serum NTX and BAP were significantly elevated in prostate cancer patients with bone metastasis compared with those without bone metastasis. No screening guidelines currently exist; however, patients at risk of decreased BMD should be screened and treated to prevent consequent fractures. Serum NTX and BAP monitoring of prostate cancer patients might facilitate the timely diagnosis of bone metastasis.
Journal
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- Journal of The Showa Medical Association
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Journal of The Showa Medical Association 67 (2), 134-140, 2007
The Showa University Society
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Details 詳細情報について
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- CRID
- 1390001204835651968
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- NII Article ID
- 130001820288
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- NII Book ID
- AN00117027
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- COI
- 1:CAS:528:DC%2BD2sXpsFOitrc%3D
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- ISSN
- 21850976
- 00374342
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- NDL BIB ID
- 8919353
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- Data Source
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- JaLC
- NDL
- CiNii Articles
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- Abstract License Flag
- Disallowed