ALBUMINURIA AND HIGH MOLECULAR WEIGHT ADIPONECTIN BETWEEN OBESE AND NON-OBESE CHILDREN

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  • 非肥満小児と肥満小児における尿中アルブミンと高分子量アディポネクチンについて
  • ヒヒマン ショウニ ト ヒマン ショウニ ニ オケル ニョウチュウ アルブミン ト コウブンシリョウ アディポネクチン ニ ツイテ

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The term metabolic syndrome refers to an apparent clustering of several findings in patients: central obesity, insulin resistance, hypertension, and dyslipidemia. Recently, albuminuria is associated with metabolic syndrome and may be an indicator of general vascular endothelial damage in adults. In this study we measured albuminuria and high molecular weight to determine whether or not in childhood adiponectin-to-total adiponectin ratios (HA/TA) and investigated that in childhood there are significant differences between obese and the non-obese subjects. A total of 69 subjects were entered into the final analysis. HA/TAs of non-obese children were 0.53 ± 0.10 (male) and 0.55 ± 0.12 (female) : those of obese children were 0.38 ± 0.13 (male) and 0.39 ± 0.08 (female) . The values of urinary albumin of non-obese children were 2.1 ± 1.5 (male) and 2.4 ± 1.4 (female) : those of obese children were 3.3 ± 3.4 (male) and 2.4 ± 3.6 (female) . The HA/TAs in the obese subjects were significantly lower than those in the non-obese subjects. However, there was no significant difference of albuminuria between the obese subjects and the non-obese subjects. Clinical data in this study showed that only uric acid in the obese subjects was higher than that in the non-obese subjects. Our study could not reveal a strong relationship between albuminuria and obesity in childhood. We suggest that renal failure in childhood, such as albuminuria, does not appear significant, but the effect of long duration obesity in children cannot be ignored. A more comprehensive and intensive management of obesity in childhood from an early stage is important to prevent the progression of renal injury. Studying the transition of albuminuria and adiponectin may provide insight concerning the health status of obese children.

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