PREVENTIVE EFFECT OF AN ORAL BISPHOSPHONATE ON OSTEOPOROSIS ASSOCIATED WITH HORMONAL THERAPY FOR PROSTATE CANCER

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  • 前立腺癌の内分泌療法による骨粗鬆症に対する経口ビスフォスフォネート製剤の予防効果に関する検討
  • ゼンリツセンガン ノ ナイブンピツ リョウホウ ニ ヨル コツソショウショウ ニ タイスル ケイコウ ビスフォスフォネート セイザイ ノ ヨボウ コウカ ニ カンスル ケントウ

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Abstract

In this study, we measured and evaluated the bone density of untreated patients with prostate cancer in order to determine bone density and examine the effect of an oral bisphosphonate on osteoporosis developed after hormonal therapy. We measured the bone density of the lumbar vertebrae, the femoral neck, the total hip and the distal radius of patients with untreated prostate cancer, without bone metastasis, with DEXA (dual energy X-ray absorptiometry). In order to evaluate the preventive effect of an oral bisphosphonate on osteoporosis developed after hormonal therapy, we followed up a total of 48 patients for more than one year from the beginning of the treatment. We measured yearly the bone density of 22 patients who agreed to take risedronate, an oral bisphosphonate (2.5 mg/day) for prevention of osteoporosis, and 26 patients who did not take risedronate, and compared the changes in bone density. As to the effect of the oral bisphosphonate on osteoporosis after hormonal therapy, the bone density of the femoral neck of the risedronate treatment group after one year decreased by 1.1% compared to the pretreatment value, while it decreased by 5.0% compared to the non-risedronate treatment group. The bone density of the lumbar vertebrae decreased by 0.6% in the risedronate treatment group and by 4.5% in the non-risedronate treatment group one year after the start of treatment. These findings suggest that the decrease of bone mineral density was greater in the femoral neck than in other locations, and the oral bisphosphonate is effective in preventing the loss of bone mass associated with hormonal therapy in patients with prostate cancer.

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