SERIAL STUDY OF ALCOHOLIC FATTY LIVER DURING ABSTINENCE

DOI
  • IIDA Yoshiki
    Second Department of Pathology, Showa University School of Medicine
  • KUSHIMA Miki
    Second Department of Pathology, Showa University School of Medicine
  • SHIOKAWA Akira
    Second Department of Pathology, Showa University School of Medicine
  • OTA Hidekazu
    Second Department of Pathology, Showa University School of Medicine

Bibliographic Information

Other Title
  • アルコール性脂肪肝の禁酒後の経時的病理組織学的変化について
  • —QUANTITATIVE ANALYSIS OF LIVER BIOPSY USING AUTOMATIC IMAGE ANALYZER—
  • ―画像解析による肝細胞内脂肪の定量的解析―

Description

It is well known that the incidence of alcoholic fatty liver is intimately related to cumulative alcohol consumption. Recently, it has been shown that alcoholic fatty liver can be reversed by total abstinence. However, there are no reports of morphological or quantitative analysis of serial liver changes during total abstinence. Ten patients with alcoholic fatty livers underwent serial liver biopsies, and quantitative change of fatty droplets was analyzed by an automatic image analyzer during total abstinence. The ratio of the area of fatty droplets to the surveyed area varied from 0.92 % to 18.33 % (average, 6.96 %) . Distribution of fatty droplets tended to be greatest in the central (pericentral vein) zone. Small sized fatty droplets were 0.72 %, intermediate sized were 4.61 % and large sized were 1.63 % of the total area. Of 10 patients with alcoholic fatty liver that were followed up, 8 showed remarkable decrease in the area of fatty droplets (8.7 %, of first biopsy) within several months of total abstinence. Especially, 4 improved patient with no complications of diabetes mellitus nor obesity, showed remarkable decrease of fatty droplets (4.17 %), and 2 diabetic patients showed less decrease (22.01 %) . Obese patient in the improvement group improved to 4.56 % improvement. In the other 2 obese patients (over 20 %), fatty droplets increased during total abstinence. Judgement of fatty metamorphosis by light microscopy seems to lead to overestimation compared to the results of the automatic image analyzer.

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Keywords

Details 詳細情報について

  • CRID
    1390001204836400128
  • NII Article ID
    130001828079
  • DOI
    10.14930/jsma1939.50.285
  • ISSN
    21850976
    00374342
  • Data Source
    • JaLC
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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