術前患者の不安並びにそれに伴なう睡眠障害に対するMinor tranquilizerの薬効について

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タイトル別名
  • THE EFFECTS OF A MINOR TRANQUILIZER FOR TREATMENT OF SLEEP DISTURBANCE WITH ANXIETY BEFORE SURGERY
  • 術前患者の不安並びにそれに伴なう睡眠障害に対するMinor tranquilizerの薬効について--Double blind methodによるMS-4101(Flutazolam)の臨床評価
  • ジュツゼン カンジャ ノ フアン ナラビニ ソレニ トモナウ スイミン ショウ
  • “CLINICAL EVALUATION OF A NEW MINOR TRANQUILIZER, FLUTAZOLAM (MS-4101) BY A DOUBLE BLIND METHOD.”
  • ―Double blind methodによるMS-4101 (Flutazolam) の臨床評価―

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抄録

Using the double blind method, new tranquilizer MS-4101 (Ro 7-6102) and placebo were compared in surgical patients. Either 10mg of MS-4101 or placebo was given orally, once daily, to patients for 3, 5 or 7 days before the day scheduled for surgical procedures. A simple scoring system based on the observation of the patient's behavior and answers to standardized questions has been used. Results were statistically analyzed. Anxiety grade of patients were classified according to Manifest Anxiety Scale (MAS) . Judging from the global evaluation of the effects based on the score of “anxiety”, “getting to sleep” and “state of sleeping”, MS-4101 was effective in the high anxiety group, particularly in the 7 days-therapy group.

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