EFFECT OF VITAMINE B<SUB>1</SUB> AND RELATED AGENTS ON THE OPERANT BEHAVIOR IN RATS
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- Okazaki Masako
- Department of Pharmacology, Showa University School of Medicine
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- Yasuhara Hajime
- Department of Pharmacology, Showa University School of Medicine
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- Kasahara Takako
- Department of Pharmacology, Showa University School of Medicine
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- Sakamoto Koji
- Department of Pharmacology, Showa University School of Medicine
Bibliographic Information
- Other Title
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- ラットオペラント行動に及ぼすビタミンB<SUB>1</SUB>および関連物質の影響
- ラットオペラント行動に及ぼすHistamineの影響
- ラットオペラント コウドウ ニ オヨボス Histamine ノ エイキョウ
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Abstract
Effect of B1and related agents on the operant behaviors in rats was studied, using a commercially available apparatus. Two schedules of the food reinforcement with a fixed ratio (FR-30) and a fixed interval (FI-60) and a schedule of discriminated avoidance response (DAR) were used for the conditioned behaviors.<BR>In the FR-30 and FI-60 schedules, B1, B1-P and B1-PP administered intraventricularly 10-50 μg/rat or subcutaneously 100-200 mg/kg, produced the dose-related decreases in the behaviors. In the DAR schedule, B1, B1-P and B1-PP did not produce significant alteration.<BR>The suppressive effect in the food reinforcement schedule by B1, histamine B1-P and B1-PP was partially antagonized by the simultaneous administration of tripelennamine, an antihistaminic.<BR>A large dose of B1caused an elevation of histamine level in the brain of mouse approximately 25%.<BR>From these results, a possibility that the suppressive effect of B1on the operant behaviors may be responsible for histamine in the brain, is discussed.
Journal
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- Journal of The Showa Medical Association
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Journal of The Showa Medical Association 37 (2), 169-175, 1977
The Showa University Society
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Details 詳細情報について
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- CRID
- 1390001204837098880
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- NII Article ID
- 130001822826
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- NII Book ID
- AN00117027
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- ISSN
- 21850976
- 00374342
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- NDL BIB ID
- 1912033
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- Data Source
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- JaLC
- NDL
- CiNii Articles
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- Abstract License Flag
- Disallowed