CHANGES OF BLOOD VISCOSITY AND HEMODYNAMICS IN ENDOTOXIN SHOCK IN DOGS

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  • エンドトキシンショックが血行動態特に血液粘度に及ぼす影響
  • エンドトキシン ショック ガ ケッコウ ドウタイ トクニ ケツエキ ネンド ニ

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Blood viscosity and hemodynamics in endotoxin shock were studied in dogs. E. Coli endotoxin (3 mg/kg LD100) was administrated intravenous to dogs which were anesthetized with pentobarbital and ventilated mechanically.<BR>Blood viscosity decreased in posttreatment with low molecular weight dextran solution (20 ml/kg) after administration of Et. (D-group) . But in another groups-administration of Et. alone (A-group), pre and posttreatment with methilpredonisolon (30 mg/kg) before and after administration of Et. (B, C-group) posttreatment with Lactated Ringer's solution (20 ml/kg) after administration of Et. (E-group) -similar increase was observed.<BR>In all groups, hematocrit increased with the advance of shock, however in B group, the rate of increase was lower than D group. There is no interrelation between blood viscosity and hematocrit was observed.

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