SU剤 (トルブタマイド) のインスリン分泌機序に関する研究

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  • 辻 正富
    昭和大学医学部大学院医学研究科内科系第一内科学

書誌事項

タイトル別名
  • A STUDY ON THE MECHANISM OF TOLBUTAMIDE-INDUCED INSULIN SECRETION
  • SU剤(トルブタマイド)のインスリン分泌機序に関する研究--特にC′-AMP系に関して
  • SUザイ トルブタマイド ノ インスリン ブンピ キジョ ニカンスルケンキュウ
  • —ESPECIALLY ON THE C'-AMP—
  • 特にC'-AMP系に関して

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抄録

Studies were performed to investigate the influence of tolbutamide on the cyclic AMP system of the islets in the normal subjects.<BR>The conclusion were as follows;<BR>1) In the insulin response to the combined stimulation of tolbutamide and glucagon, which stimulates adenylcyclase, a synergistic effect was observed.<BR>2) The insulin response to glucagon was markedly enhanced by tolbutamide.<BR>3) Isoproterenol, which stimulates adenylcyclase, enhanced tolbutamide-induced insulin secretion<BR>4) Tolbutamide-induced insulin secretion was not enhanced by aminophylline which inhibits phosphodiesterase, but glucagon-induced insulin secretion was enchanced.<BR>5) From the results as above, it seems that tolbutamide inhibits phosphodiesterase in the B-cell of islets.<BR>6) In each experiments, the increase of C-peptide showed a close correlation with that of insulin, and C-peptide was considered significantly to reflect the insulin secretion.<BR>7) Peak levels of C-peptide occurred later than those of insulin and C-peptide decreased slowly to basal levels. The molar concentration of C-peptide were greater than insulin. Molar ratio (CPR : IRI) at peak levels was from 1.3 to 3.13.

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