Monoamine Oxidaseに関する研究 (第52報)

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  • 粟屋 保男
    昭和大学医学部大学院医学研究科病理系第二薬理学

書誌事項

タイトル別名
  • STUDIES ON MONOAMINE OXIDASE (REPORT 52)
  • Monoamine Oxidaseに関する研究-52-ヒト胎盤MAOに対する金属イオンの影響
  • Monoamine Oxidase ニカンスルケンキュウ 52 ヒト タイバン
  • EFFECTS OF METALS ON MONOAMINE OXIDASE ACTIVITY IN HUMAN PLACENTA
  • ―ヒト胎盤MAOに対する金属イオンの影響―

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抄録

Effects of various metal ions on monoamine oxidase (MAO) in human placenta were studied. Both MAO activities with serotonin and tyramine as substrate were inhibited by NaCI in almost the same degree. Similar results as the case of NaCI were obtained with KCI, MgC12 and HgC12 administration. The potent inhibitions of MAO activity with serotonin as substrate than with tyramine were observed by the administrations of CdCl2 and K2CrO4, and CaCl2 caused more potent inhibition of MAO activity with tyramine as substrate than with serotonin. On the other hand, MnC12 at concentrations from 10 μM to 0.1 M caused increase of MAO activity with serotonin as substrate, whereas it caused inhibition of MAO activity with tyramine. These effects of MnC12 on MAO activity were found to be irreversible and noncompetitive. No effects on optimum pH and optimum PS of MAO acti-vity with serotonin as substrate were observed by the administration of MnC12. However, in case of tyramine used as substrate MnC12 caused changes in optimum pH from 8.0 to 7.0 and in optimum PS from 1 mM to 20 mM.<BR>The effects of MnC12 on MAO activity were not influenced by the changes in oxygen concentration in gas phase. From these results, it was suggested that there were at least two different types of MAO in human placenta, one of these mainly oxidize serotonin and the other mainly oxidize tyramine.

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