塩化コバルト注射に伴う家兎の高トリグリセライド血症について

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タイトル別名
  • HYPERTRIGLYCERIDEMIA INDUCED BY THE INJECTION OF COBALT CHLORIDE IN RABBITS
  • エンカ コバルト チュウシャ ニ トモナウ カト ノ コウ トリグリセライド

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1. Changes in concentrations of plasma triglyceride and FFA were investigated in the starved rabbits, in which cobalt chloride was administered once a day for eight consecutive days and compared with those of starved rabbits. Concentration of plasma triglyceride in cobalt-treated animals began to increase after injection and rose to the level of 600-700 mg/dl on the average after 120 hr. In the starved control rabbits, plasma triglyceride changed within the normal range and rose to the level over 100 mg/dl after 144 hr. Plasma FFA concentration in cobalt-treated rabbits was elevated rapidly after injection and fluctuated thereafter in the range of 300-500 μEq/L, while in the starved controls it changed in parallel with that of the former, but remained higher throughout the experiment<BR>2. Starved rabbits were injected with cobalt chloride once a day for three days and following items were compared with normal fed or starved control rabbits.<BR>a. Cobalot chloride administration induced six times higher plasma triglyceride, and twice higher hepatic triglyceride than those of starved animals, while plasma FFA remained in lower level than that of starved control<BR>b. Plasma free glycerol concentration was increased in cobalt-treated animals, but no significant decrease could be observed in starved control.<BR>c. Hepatic α-glycerophosphate content showed no change either in starved or in cobalt-treated animals.<BR>d. In cobalt-treated animals, blood glucose level was slightly higher, but no significant change could be seen in blood lactate and pyruvate concentration, as compared with those of starved control and normal fed animals<BR>e. Hepatic glucose fluctuated in parallel with blood glucose. Heptic lactate arranged in order of decreasing content was : normal feed, starved control, and cobalt-treated, whereas hepatic pyruvate was of the reversed order as the former.

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