ダンピング症候群における症状の分析と化学物質との関係

Patients after gastrectomy were tested whether they would produce dumping syndrome or not. 40 patients were diagnosed as dumper and then serotonin, histamine and bradykinin like substance in their blood and catecholamine in their urine were measured. At the same time relationship between symptoms and these chemical substances were studied. The results are as follow.<BR>(1) The manifested symptoms were classified as 206 items. The average items for each patient was 5.15 items.<BR>(2) The most manifested symptom was nausea (72.5%) and then flushing face, fatiga-bility (52.5%), palpitation, a feeling of fever, and intestinal sounds (50%) in order. No syncope was observed.<BR>(3) Judging from the manifestation time of symptoms, flushing face, a feeling of fever, fever, strangling chest pain, palpitation, and headache appeared earlier and such symptoms as fatigue, dyspnea, dizzines, vomiting, sweating, drowsiness and diarrhea appeared relatively later.<BR>(4) Such symptomatic combination as nausea and fatigability, nausea and flushing face, intestinal sounds and f atigability seemed to appear easily. This fact suggest that there are some relationship between these symptoms.<BR>(5) To analyze the interrelation between these symptoms and four chemical substances, the data was analyzed by the numerical theory, I, one of analytic function of several variables.<BR>(6) As the results, the most closed correlation between the symptoms with serotonin in blood are a feeling of fever and intestinal sounds, and the fairly closed correlative symptoms are dizziness, sweating, dyspnea, headache and nausea.<BR>(7) The closed correlative symptoms with histamine in blood are headache and gastric heaviness, and the fairly closed correlative symptoms are a strangling chetpan dyspnea, vomiting, intestinal sounds, diarrhea and abdominal pain.<BR>(8) The closed correlative symptoms with bradykinin like substance are dizziness, sweating, flushing face and a feeling of the abdomianal fullness, and the fairly closed correlative symptoms are dyspnea, headache, nausea, vomiting, diarrhea and a feeling of ptosis of the stomach.<BR>(9) The closed correlative symptoms with cathecolamine in urine are a strangling sensation of the breast, palpitation, sleepiness, dyspnea and nausea, and the fairly closed correlative symptoms are sweating, dyspnea, a feeling of fever, fatigue, vomiting, abdominal pain and a feeling of the abdomianal fullness.<BR>(10) I think in the test of the induced dumping syndrome serotonin and catecholamine release earlier than histamine and bradykinin.<BR>(11) As above mentioned, it becomes clear that several chemical substances participate complicatedly in dumping syndrome.