STUDIES ON MONOAMINE OXIDASE

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  • Monoamine Oxidaseに関する研究
  • Monoamine oxidaseに関する研究-14-異常条件下におけるラットMonoamine oxidase(MAO)活性
  • Monoamine oxidase ニ カンスル ケンキュウ 14 イジョウ ジョウケン カ ニ オケル ラット Monoamine oxidase MAO カッセイ
  • Report 14: Monoamine Oxidase in Rat leaving under the several Abnormal Conditions
  • 第14報異常条件下におけるラットMonoamine Oxidase (MAO) 活性

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Monoamine Oxidase (MAO) [EC. 1. 4. 3. 4. monoamine: O2 oxidoreductase (deaminating) ] in rat under the several abnormal conditions such as starvation, dehydration or fasting was studied and following results were obtained.<BR>1) During 9 days starvation, rats lost 50% of the body weight. The ratio of organs weight against body weight decreased. Especially in liver, the ratio decreased markedly to about 60% of the control.<BR>2) During 7 days starvation, MAO activity decreased to parallele with the decrease of the organs/body weight ratio and thereafter it increased gradually.<BR>3) Following 9 days starvation, succinic dehydrogenase activity in rat liver increased as same as in case of MAO. On the contrary, remarkable decrease was observed in case of cytochrome oxidase activity.<BR>4) The pattern for MAO, succinic dehydrogenase and cytochrome oxidase activity in liver and brain effected by a 9 days starvation differed notably.<BR>5) The substrate specificity for MAO in rat liver following 9 days starvation was studied. To any substrates tested, MAO activity increased remarkably. When 5-hydroxytryptamine was used as the substrate, MAO activity in brain was approximately 2-fold than that of the control.<BR>6) Michaelis Constants were calculated by the Lineweaver Burk's method. In case of the control, Km value of MAO was 1.0×10-2M, while 7.1×10-3M was calculated in case of 9 th day starvation. Feeding following the starvation caused recovery of Km value to the control level.

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