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- MATSUNAGA Akihiro
- Department of Orthopaedic Surgery, Showa University School of Medicine
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- TOYOSHIMA Yoichi
- Department of Orthopaedic Surgery, Showa University School of Medicine
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- YOSHIKAWA Yasushi
- Department of Orthopaedic Surgery, Showa University School of Medicine
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- SHIBUKI Takashi
- Department of Orthopaedic Surgery, Showa University School of Medicine
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- KAJI Yasutaka
- Department of Orthopaedic Surgery, Showa University School of Medicine
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- SUKEZAKI Fumio
- Department of Orthopaedic Surgery, Showa University School of Medicine
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- INAGAKI Katsunori
- Department of Orthopaedic Surgery, Showa University School of Medicine
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- NAKAMURA Masanori
- Showa University Northern Yokohama Hospital
Bibliographic Information
- Other Title
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- 人工股関節置換術後に診断しえたアルカプトン尿症の1例
- 症例報告 人工股関節置換術後に診断しえたアルカプトン尿症の1例
- ショウレイ ホウコク ジンコウ コ カンセツ チカン ジュツゴ ニ シンダン シエタ アルカプトン ニョウショウ ノ 1レイ
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Abstract
We encountered a case of degenerative osteoarthritis due to alcaptonuria, an inherited disorder of tyrosine metabolism. A 58-year-old woman was admitted to our hospital due to hip pain. A hip simple X-ray picture revealed terminal stage of degenerative hip osteoarthritis. A simple lumbar X-ray showed calcification of multiple lumbar discs, which was suggestive of alcaptonuria. During total hip osteoarthroplasty surgery, we noted black coloration (ochronosis) of the femoral neck, a characteristic sign of alcaptonuria. Alcaptonuria was eventually diagnosed by black coloration of the urine and detection of homogentisate in the urine using gas chromatography-mass spectrometry method. Although gait disturbance and hip pain disappeared after total hip arthroplasty surgery, careful follow-up is necessary for early detection of various complications of alkaptonuria in other organs.
Journal
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- Journal of The Showa Medical Association
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Journal of The Showa Medical Association 72 (1), 133-137, 2012
The Showa University Society
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Keywords
Details 詳細情報について
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- CRID
- 1390001204840026112
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- NII Article ID
- 130002582885
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- NII Book ID
- AN00117027
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- ISSN
- 21850976
- 00374342
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- NDL BIB ID
- 023997411
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- Text Lang
- ja
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- Data Source
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- JaLC
- IRDB
- NDL
- CiNii Articles
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- Abstract License Flag
- Disallowed