か牛神経複合活動電位ならびにか牛内直流電位に及ぼすグルタミン酸アゴニストの影響

DOI

書誌事項

タイトル別名
  • Effect of Glutamate Agonist on the Compound Action Potential and the Endocochlear DC Potential of Gerbils

抄録

Effect of AMPA (a-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid), a glutamate agonist, on the compound action potential (CAP) and endocochlear DC potential (EP) was investigated in gerbils. AMPA 100μM, AMPA 200μM, sucrose 200μM, and artificial perilymph were administered via Gelfoam placed on the round window membrane. Artificial perilymph or sucrose 200μM did not markedly change the CAP threshold, but it gradually increased in response to AMPA 100μM or 200μM. EP, on the other hand, did not change markedly after administration of artificial perilymph or AMPA 100μM, but it decreased after administration of AMPA 200μM and sucrose 200μM. These findings suggest that the stria vascularis is not influenced by glutamate excitotoxicity, which devastates the inner hair cells and the spiral ganglion neurons. The decrease in EP in the AMPA 200μM group appears to have be due to the high osmotic gradient of the solution.

収録刊行物

キーワード

詳細情報 詳細情報について

  • CRID
    1390001204841576832
  • NII論文ID
    130003713233
  • DOI
    10.4295/audiology.46.262
  • ISSN
    18837301
    03038106
  • 本文言語コード
    ja
  • データソース種別
    • JaLC
    • Crossref
    • CiNii Articles
  • 抄録ライセンスフラグ
    使用不可

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