Kanendomycin, Vistamycinの聴器におよぼす影響に関する電子顕微鏡的研究
書誌事項
- タイトル別名
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- Electron Mincroscopic Study of Kanendomycin and Vistamycin Ototoxicity
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The ototoxic effects of kanendomycin and vistamycin on mice were studied by light and electron microscopy.<br>Toxic reaction were mainly observed in the organ of Corti. Degeneration appeared first in the outer hair cells in the basal turn of the cochlea starting with the increasing of lysosomes, proliferation of smooth endoplasmic reticula and degeneration of mitochondria in the subcuticle area and resulting in the complete loss of hair cells, but the stria vascularis and spiral ligament showed little change. Even after the disappearance of the hair cells, some nerve endings were still present in the organ of Corti but they were also disintegrated in a large dose administration. The degeneration of mitochondria and increasing of lysosomes which were observed one day after the final injection of these dregs were much decreased in long term observation.<br>Even in case of total loss of the outer hair cells in the basal turn, some of the outer hair cells in the hook region still existed.<br>Vistamycin was less ototoxic than kanendomycin.
収録刊行物
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- AUDIOLOGY JAPAN
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AUDIOLOGY JAPAN 15 (3), 202-210, 1972
一般社団法人 日本聴覚医学会
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詳細情報 詳細情報について
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- CRID
- 1390001204842114688
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- NII論文ID
- 130003710794
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- ISSN
- 18837301
- 03038106
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- データソース種別
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- JaLC
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- 使用不可