Streptomycin hearing loss and genetic predisposition to hearing loss of cochlear origin

DOI 21 References

Bibliographic Information

Other Title
  • ストレプトマイシンによる難聴と内耳の遺伝性素因

Description

With the discovery of streptomycin (SM), the mortality of pulmonary tuberculosis declined markedly in Japan. The incidence of hearing loss, however, as an important adverse effect of the drug, has been increasing steadily year by year. Hearing loss induced by SM is sometimes familial, when it is referred to as “familial SM deafness”.<br>Analysis of the pedigrees of patients with familial SM hearing loss has suggested that familial SM deafness may be related to a genetic predisposition to hearing loss of cochlear origin.<br>It has been suggested that familial SM hearing loss may be inherited via a 1555 mutation of the mitochondria DNA.<br>Two patients with pedigrees are presented and discussed.

Journal

  • AUDIOLOGY JAPAN

    AUDIOLOGY JAPAN 53 (6), 653-663, 2010

    Japan Audiological Society

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Keywords

Details 詳細情報について

  • CRID
    1390001204842482432
  • NII Article ID
    130004544892
  • DOI
    10.4295/audiology.53.653
  • ISSN
    18837301
    03038106
  • Text Lang
    ja
  • Data Source
    • JaLC
    • Crossref
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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