Clinicopathologic significance of mucinous breast carcinoma subclassification

DOI Web Site Web Site 27 References
  • KASHIWAGI Shinichiro
    Department of Surgical Oncology, Osaka City University Graduate School of Medicine
  • ASANO Yuka
    Department of Surgical Oncology, Osaka City University Graduate School of Medicine
  • WATANABE Mao
    Department of Surgical Oncology, Osaka City University Graduate School of Medicine
  • MORISAKI Tamami
    Department of Surgical Oncology, Osaka City University Graduate School of Medicine
  • AOMATSU Naoki
    Department of Surgical Oncology, Osaka City University Graduate School of Medicine
  • KAWAJIRI Hidemi
    Department of Surgical Oncology, Osaka City University Graduate School of Medicine
  • IKEDA Katsumi
    Department of Breast-Surgical Oncology, Osaka City General Hospital
  • TAKASHIMA Tsutomu
    Department of Surgical Oncology, Osaka City University Graduate School of Medicine
  • OGAWA Yoshinari
    Department of Breast-Surgical Oncology, Osaka City General Hospital
  • ONODA Naoyoshi
    Department of Surgical Oncology, Osaka City University Graduate School of Medicine
  • ISHIKAWA Tetsuro
    Department of Surgical Oncology, Osaka City University Graduate School of Medicine
  • WAKASA Kenichi
    Department of Diagnostic Pathology, Osaka City University Graduate School of Medicine
  • HIRAKAWA Kosei
    Department of Surgical Oncology, Osaka City University Graduate School of Medicine

Bibliographic Information

Other Title
  • 乳腺粘液癌における細分類の臨床病理学的意義
  • ニュウセン ネンエキガン ニ オケル サイブンルイ ノ リンショウ ビョウリガクテキ イギ

Search this article

Description

Mucinous breast carcinoma is an invasive neoplasm with clusters of tumor cells floating in pools of extracellular mucin. Pure mucinous breast carcinoma needs to be differentiated from mixed mucinous breast carcinoma, also known as invasive ductal carcinoma with a mucinous component. Pure mucinous breast carcinoma can be subclassified into a hypocellular variant (type-A) and a hypercellular variant (type-B). In this study, we classified 42 cases of mucinous breast carcinoma identified in a sample of 1,041 breast carcinomas and examined the significance of the mucinous breast carcinoma subclassification. Mucinous breast carcinoma patients were more frequently hormone receptor-positive (p=0.001) and HER2 expression-negative (p=0.002) compared to non- mucinous breast carcinoma patients. The disease-free interval of mixed mucinous breast carcinoma patients was shorter than that of pure mucinous breast carcinoma patients. A multivariate logistic regression analysis showed that high nuclear grade was significantly correlated with disease-free survival (p=0.003). In this study, the mucinous breast carcinoma subclassification was found to be useful for determining appropriate treatment.

Journal

References(27)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top